Isaac C. Rottenberg was born in London, England, and was baptized in the Presbyterian Church. From age three he lived in the Netherlands. After the Nazi occupation of Holland, which led to the death of many of his relatives and friends, including his father, Isaac studied law at the University of Leiden. In 1948, he and his wife Malwina, who had spent several years in a Nazi concentration camp, moved to the United States where he studied theology. Isaac wrote from a broadly Reformed perspective, but over the years he maintained close relationships with leaders in Evangelical, Roman Catholic, and Jewish circles.